Dermal permeation enhancement high-throughput analysis

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DrDave
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Dermal permeation enhancement high-throughput analysis

Pharmaceutical Research
19 (5): 655-660, May 2002

Pankaj Karande& Samir Mitragotri from the Department of Chemical Engineering, University of California, Santa Barbara
recently reported a "novel high throughput (HTP) method that is at least 50-fold more efficient in terms of skin utilization and up to 30-fold more efficient in terms of holdup times than the current methods for formulation screening (Franz diffusion cells)....
They have developed a high throughput method was based on skin conductivity and mannitol penetration into the skin. This method was used to perform at least 100 simultaneous tests per day. "

I work evaluating permeation enhancers solely with Franz cells and structiural analysis. The claims made by these fellows blows me away.
I've attempted communication repeatedly with them to no avail. It seems this work was just a technical class project that has ceased to progress after their paper was published.

Has anyone touched on this technology?

Sandy
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DrDave wrote:Pharmaceutical

DrDave wrote:

Pharmaceutical Research
19 (5): 655-660, May 2002

Pankaj Karande& Samir Mitragotri from the Department of Chemical Engineering, University of California, Santa Barbara
recently reported a "novel high throughput (HTP) method that is at least 50-fold more efficient in terms of skin utilization and up to 30-fold more efficient in terms of holdup times than the current methods for formulation screening (Franz diffusion cells)....
They have developed a high throughput method was based on skin conductivity and mannitol penetration into the skin. This method was used to perform at least 100 simultaneous tests per day. "
I work evaluating permeation enhancers solely with Franz cells and structiural analysis. The claims made by these fellows blows me away.
I've attempted communication repeatedly with them to no avail. It seems this work was just a technical class project that has ceased to progress after their paper was published.
Has anyone touched on this technology?

Sometimes scientists sell their rights to the university which will patent the innovation and keep it within the company or the university. If you cannot find more publication regarding this new method, you might check Ph.D. thesis written under their names.