4-methyl pipecolic acid analytical method on hplc or gc

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bharatpatil
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4-methyl pipecolic acid analytical method on hplc or gc

Please suggest any method for 4-methyl pipecolic acid on gc or hplc for their Diastereomer

Dr. Analytical
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This compound will probably

This compound will probably not be volatile, so a GC method will not work. 

You may be able to separate the diastereomers on a standard reversed phase column using a slightly acidic mobile phase.  If you get no separation, then a chiral column may be necessary.