Compounds that control kinases activity have a great interest in drug development. Kinases are enzymes that catalyze phosphorylation and therefore are involved in different diseases such as cancer. Scientists have used different tools to screen kinases such as kinase profiling by radioactive assay or fluorescence-polarization method. I have heard that kinase inhibitors fail most of the time to deliver what they claim. Does anyone know names of companies and test kits used for kinase screening? also kits that track signal-transduction pathways, I need to set up an experiment to observe the effect of an antibody in signal-transduction within the cell. Are any products available to observe these activities inside the cell?