ABSTRACT OF THE DISCLOSURE
The invention provides a device, method, system and program for intelligent in vivo cell-level chemical or genetic material delivery; wherein multiple injectable biocompatible physical delivery device containers are used to selectively administer medicine, chemical(s) or genetic materials to a target cell in a patient, human or animal, with reduced systemic toxicity; said delivery device container includes an internal contents-to-cell transfer mechanism, usually a syringe; a biological key molecule, magnetic device or vibration frequency signature sensor placed on the surface of the delivery device container which is adapted to selectively bind to said target cell directly or indirectly; a tag placed on the surface of the delivery device container, usually metallic and biocompatible in nature, which will display to an observer when scanned through external devices such as x-ray, MRI, CT, sound, etc.; and a release mechanism to move the internal contents of the delivery device container into said target cell over a predetermined and specified timed basis.
EMERGING TECHNOLOGY FOR USE WITH NANO CONTAINER
University of California, Los Angeles, has developed a nano-acoustical sensor that allows the natural vibration of cells to be a tumor marker. Healthy cells (yeast cell, 1,000 vibrations per second) are expected to have vibration signatures different from unhealthy cells.
Georgia Tech is using a molecular beacon for early cancer diagnosis and therefore marking -- based on the cancer-caused mutations of mRNA within the target cell.
Georgia Tech is developing a magnetic field guidance system for tumor marking -- directing magnetic (our metal nano container) particles to a tumor cell.
Georgia Tech has developed a self-assembling nano spring that will be used for the carrier-to-cell deployment mechanism. The spring is piezoelectric.
Australian National University has built a tiny generator that converts low level background vibration into electricity allowing full power to our container when attached to a vibrating cell.
Our nano container will use the generator for a killing electric shock to a target cell.
MIT has developed nano quantum dots that emit light in various wave lengths. A second killing approach will use the heat from the light via the generator above to kill the target cell.
Stanford University has developed carbon nanotube based molecular electric circuits that can be used inside our nano container.
General Electric and IBM have developed computer algorithms for optimization of specific material properties allowing our amorphous metal shell to be optimized for specific body applications.
Institute for Bioengineering and Nanotechnology, Singapore, have synthesized nanoparticles with precisely defined pores for controlled delivery of drugs or for gene therapy our container will deliver the nanoparticles.
University of California, Berkeley, is using nano quantum dots to tag proteins inside cells for tumor markers.
University of California, Berkeley, has developed a nano switch that will allow the generator above to build a charge before release of the energy to kill the target cell.
Freie University, Berlin, has developed polymer based nano tubes that will also function as our container as application requirements warrant.
University of Texas, Austin, has developed nano transfer printing for patterning nano scale features.
Northwestern University has developed a manufacturing approach for build zeptoliter containers which are 50 nanometers across.
Imperial College, London, has developed nano materials that automatically reshape themselves in response to chemical changes in the body allowing new container-to-cell delivery devices.
Northwestern University has developed a light based fingerprint of cancer cells allowing another marker approach.