Protocol for: Dynamic X-ray Imaging of Iodinated Contrast-Agent Clearance
Abstract or Description:
Chronic kidney disease (CKD) currently affects approximately 23 million people in the United States alone.As such, scientists are actively researching ways to treat and slow the progression of such ailments. The primary means of studying the onset and progression of CKD and other renal disorders is to measure the glomerular filtration rate (GFR). Current methods of measuring kidney function involve the observation of creatinine and inulin clearance. Progression of CKD presents with a reduction in GFR, as measured by reduced creatinine and inulin clearance rates. Studies utilizing nonradioactive iodine X-ray contrast media have more recently been used in order to measure renal insufficiency. Iodinated contrast agents are a reliable measure of GFR through a bolus injection followed by blood sampling. This technique is used both in laboratory rats and in the clinic because the rate of contrast agent clearance can be measured reproducibly. Furthermore, administration of iodinated X-ray contrast media (iodixanol) produces no major changes in glomerular filtration rate and is a safe diagnostic tool in patients with kidney functions ranging from normal to end-stage renal disease.