Description of event:
The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer
May 19—23, 2013
Hyatt Regency Monterey, Monterey, California, USA
Meeting Summary
Metazoans have evolved
pathways that regulate the size of
organs. One of the key
pathways is known as the Hippo
pathway. Research on the Hippo
pathway has grown exponentially during the past eight years, revealing a complex
signaling network. When components of the network are affected by
genetic lesions or are abnormally expressed, this leads to
cancer. The main effectors of this
pathway, YAP and TAZ, are transcriptional co-activators, which act as stemness factors and potent oncogenes. The applicants co-organized two Hippo workshops in Rome, Italy in 2009 & 2010, during which several paradoxes in the field emerged. We realized that the fast progress in this field is due to an active dialog between
Drosophila geneticists and
mammalian signalers. The overwhelming interest of researchers in the function of the Hippo
pathway in
stem cells and
cancer prompted us to seek a larger forum. This conference aims to: 1. define why YAP and TAZ function as either oncogenes or
tumor suppressors; 2. identify
membrane complexes, which activate the Hippo
pathway in mammals, as the orthology with the fly receptors is not clear; and 3. define targets for small molecule
inhibitors and activators within
pathway components based on structured modules, including WW, PDZ and SARAH domains. This conference will bring together
Drosophila geneticists, basic and
clinical cancer researchers and the
stem cell research community in order to consolidate the emerging field and have an impact on development of new
cancer therapies.
General information
Hyatt Regency Monterey is located on the magnificent Monterey Peninsula whch has been described as the great meeting of land, sea and sky. Old town Monterey is just 15 minutes away by taxi or rental car and offers a great variety of restaurants, historic architecture, and fabulous vistas. Other area attractions include; Cannery Row, Fisherman's Wharf, Monterey Bay Aquarium, Carmel and Pebble Beach. The Hyatt Regency Monterey has a 24-hour
automated business center, poolside fitness center, full service racquet club, bicycle rentals, 18 hole golf course and much more. Three restaurants and bars make it easy to sit back, relax and mix with other scientists.
Conference Location
Hyatt Regency Monterey
1 Old Golf Course Road
Monterey, California 93940-4908
USA
Contact us
Keystone Symposia
160 U.S. Highway 6, Suite 200
PO Box 1630
Silverthorne, CO 80498