Description of event:
Mitochondria, Metabolism and Myocardial Function – Basic Advances to Translational Studies
Scientific Organizers: Michael N. Sack and Roberta Gottlieb
February 3—8, 2013
Keystone Resort, Keystone, Colorado, USA
Meeting Summary
The most common causes of
heart failure are coronary artery
disease, high
blood pressure and diabetes. Mitochondrial perturbations have been associated with
heart failure itself and with most of the other preceding risk factors. In some cases mitochondrial dysfunction may play a causal role while in others
mitochondria are a central target responsible for organ dysfunction. Understanding mitochondrial pathophysiology and identifying ways to ameliorate mitochondrial dysfunction are critical to therapy for cardiovascular
disease. The continuous contractile function of the
heart is required to sustain
blood oxygenation, systemic circulation and nutrient supply to the body. This activity results in an unrelenting demand for energy production that is predominantly supported by mitochondrial oxidative
phosphorylation. It is therefore not surprising that the
mitochondria comprise about one third of cardiomyocyte volume, exhibit a promiscuous capacity to use energy
substrates and possess biologic plasticity to maintain bioenergetic homeostasis. The centrality of
mitochondria to sustain cardiac bioenergetics is additionally reflected in the development of cardiac
pathology when
mitochondria are dysfunctional. To counter this, a myriad of innate adaptive mitochondrial homeostatic programs are being identified. In the last two decades the investigations into mitochondrial
biology with ever-increasing discovery technologies have enabled the scientific community to identify many novel programs controlling mitochondrial and
metabolic function. The
objectives of this conference are to: 1) Highlight the emerging adaptive programs identified in the
heart orchestrating optimal mitochondrial homeostasis; 2) Review how the emerging risk factors of obesity and diabetes disrupt mitochondrial and cardiac function; and 3) Explore emerging
metabolic targets for
therapeutic interventions to modulate mitochondrial and
metabolic perturbations associated with cardiac
pathology.
General information:
Keystone Resort, only 90 minutes from Denver International Airport, is a year round comprehensive resort spanning seven miles along the Snake River and nestled in the White River National Forest. Keystone offers extensive experiences for conferees and their families and guests, including over 3,000 acres for skiing and riding, tubing hill, Nordic Center for snow shoeing, cross country and skate skiing, a 5 acre lake for ice skating, and horse drawn sleigh rides. Keystone Lodge has a renovated spa with ten treatment rooms, relaxation room, men's and ladies spa locker rooms. There are numerous heated swimming pools and hot tubs for relaxing. Choose from over twenty five restaurants for casual and fine dining; and two of the fine dining restaurants are AAA Four Diamond and Zagat rated. A complimentary intra-resort shuttle provides access to all attractions and activities.
Location:
Keystone Resort
21996 US Highway 6
PO Box 38
Keystone, Colorado 80435-0038
USA
Contact us:
Keystone Symposia
160 U.S. Highway 6, Suite 200
PO Box 1630
Silverthorne, CO 80498