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Apoptosis and Cancer
Jun 14, 2012 - Jun 15, 2012
Event Type: Conference
Location: Cambridge, UK
Registration Deadline: May 31, 2012
Abstract Submission Deadline: None
Description of event:
A failure of cells
to undergo apoptosis
is a common feature of many cancers. During the last 20 years, work in many laboratories has led to the identification and understanding of many of the key players involved in apoptosis
. This conference will highlight recent developments in our current
understanding of the cellular role of some of these proteins
as well as how our knowledge of the basic cellular apoptotic pathways
is being used to develop targeted cancer
Particular attention will be paid to novel agents that are currently in development or early clinical
trials to exploit our understanding of the Bcl-2 family, the p53 family, death receptors and inhibitor
of apoptosis proteins
(IAPs). Discussion sessions will involve members from academia as well as industry.
David Andrews (MacMaster University, Canada)
Mechanisms of mitochondrial membrane
permeabilization by pro-apoptotic Bcl-2 family proteins
Vishva Dixit (Genentech, US)
The Inflammasome: What are the NOD sensors sensing?
Gerard Evan (University of Cambridge, UK)
How to kill cancer cells
Anthony Letai (Dana-Farber Cancer
therapy with mitochondrial BH3 profiling
Death Receptors and Inflammation
Downing College, University of Cambridge
1 Kendall Square, Suite B2304
Cambridge, MA 02139-1517