Event Type: Conference
Location: Cambridge, UK
Registration Deadline: May 31, 2012
Abstract Submission Deadline: None

Description of event:

Apoptosis and Cancer

Description

A failure of cells to undergo apoptosis is a common feature of many cancers. During the last 20 years, work in many laboratories has led to the identification and understanding of many of the key players involved in apoptosis. This conference will highlight recent developments in our current understanding of the cellular role of some of these proteins as well as how our knowledge of the basic cellular apoptotic pathways is being used to develop targeted cancer chemotherapeutic agents.


Particular attention will be paid to novel agents  that are currently in development or early clinical trials to exploit our understanding of the Bcl-2 family, the p53 family, death receptors and  inhibitor of apoptosis proteins (IAPs).  Discussion sessions will involve members from academia as well as industry.

Invited speakers

    David Andrews (MacMaster University, Canada)
         Mechanisms of mitochondrial membrane permeabilization by pro-apoptotic Bcl-2 family proteins


    Vishva Dixit (Genentech, US)
         The Inflammasome: What are the NOD sensors sensing?


    Gerard Evan (University of Cambridge, UK)
         How to kill cancer cells


    Anthony Letai (Dana-Farber Cancer Institute, US)
         Personalizing cancer therapy with mitochondrial BH3 profiling

Topics

    BCL2 Family
    P53 Family
    Death Receptors and Inflammation
    IAP's

Venue
    Downing College, University of Cambridge

Location
    Cambridge, UK


Contacts:

1 Kendall Square, Suite B2304
Cambridge, MA 02139-1517
USA

Conference Website:
http://www.abcam.com/index.html?pageconfig=resource&rid=14653