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Biological Systems Design
Jul 13, 2012 - Jul 13, 2012
Event Type: Conference
Location: California, United States of America
Registration Deadline: Jun 29, 2012
Abstract Submission Deadline: None
Description of event:
Biological Systems Design
California, United States of America
The complexity of the genomic
structure and our limited understanding of biological processes require new computational methods to investigate the huge number of possible designs for circuits, pathways
, and entire genomes
, with the ideal being the ability to model, simulate and redesign a biological system in-silicon prior to fabrication, similar to CAD/CAM for physical devices.
Synthetic Biology aims to establish a standard and effective biological design flow, where biological systems are designed and verified computationally, before in vitro synthesis and in vivo experiments. Each phase of this process has multiple challenges ranging from managing high-throughput laboratory operations to developing new software and defining accurate and interoperable computational models.
The Special Interest Group in Biological Systems Design (BSD-SIG) aims to provide a broad view of the current state-of-the-art to scientists from biology, chemistry, computer science, mathematics and engineering.
- Jef D. Boeke, Johns Hopkins University
- Christodoulos A. Floudas, Princeton
- Dan Gusfield, UC Davis
- Nathan J. Hillson, Joint BioEnergy Institute
- Christina Smolke, Stanford University
The availability of high-fidelity techniques for the synthesis of long DNA strands constitutes the starting point for effective pathway engineering. The design of genes and, recently, chromosomes requires the introduction of new and large-scale computational methods to construct synthetic DNA sequences with specific features. The aim of this session is to present state-of-the-art methods for genome design, focusing, but not limited to, the following topics:
An important purpose of synthetic DNA is to express non-native or human-designed proteins. Protein expression and design introduce additional complexities. This session provides a forum to discuss the recent advances in the field, with particular emphasis on the design of therapeutic peptides and proteins. We invite submission on the following topics:
Computer Aided Design Tools
The design of biological systems is often characterized by ad hoc, human-centric procedure, which limit applications to small-scale problems. While Computer-Aided-Design (CAD) tools are standard in many engineering fields, CAD capabilities for synthetic biology are at a very early stage. This session gives a broad view of some emerging approaches in Biological Design Automation (BDA), with the aim of finding and discussing new areas where CAD tools can improve and accelerate the synthesis of living matter. The session will focus on:
- Design tools
- Simulation and verification methods
- Automatic design techniques
The enormous amount of data generated by high-throughput techniques and synthesis processes requires the introduction of new and specific representation schemes, along with efficient and open standards for interfacing different data sources. New systems are also required to collect information and perform- ing on-line data analysis. The aim of this session is twofold: first, exploring data structures and representations for synthetic biology; second, promoting and discussing use-case scenarios for the Synthetic Biology Open Language (SBOL). The session is centered on but not limited to:
ISCB Conferences Director