1.Development of new version of
Peptide Library based Homology Search Tool (PLHoST).
Project Description: The PLHoST consist of two modules namely Find Longest Conserved
Peptide and Annotate unknown protein. The PLHoST is written in C, PERL, CGI, Java and the database used for this software is MySQL.
2. Development of Comprehensive
Peptide Signature Database CoPSPATH of known completely sequenced pathogenic bacteria.
Project Description: CoPSPATH is a collection of 63485 invariant
peptide signatures which are extracted from 87 pathogenic bacterial genomes with a minimum occurrence in 7 organisms using PLHOSTFA
Peptide Library based Homology Search Tool approach. The graphic interface of CoPSPATH has been designed in ASP and HTML. The RDBMS used is MS Access and the back end logic for data downloading and data loading has been written in Java and PERL.
3. Development of MPI – Peplib.
Project Description: MPI-Peplib is a web based bacterial
peptide library generation tool.
There are 228 bacterial genomes are available. Parallel
peptide library can be generated using 288 node XC HP cluster .Parallel code is written in C using compatible for HP cluster. Front end is written in JSP using APACHE TOMCAT as webserver.
4. Evaluation of Genocluster.
Project Description: Genocluster is an integrated software developed as IGIB and Jalaja technology, Banglore joint project. It contains four different softwares PLHoST,GeneD’cefer,Proteome Calculator and SeaPath.
5. In-silico DRUG TARGET VALIDATION utilizing CoPSPATH database .
Project Description: CoPSPATH(Comprehensive
Peptide Signature Database of Pathogenic Bacteria) database contains 64,485 invariant
peptide signatures from 87 pathogenic bacteria. As for the CoPS database (Prakash et al., 2004), the
peptide signatures of CoPSPATH are conserved in at least seven pathogenic organisms with a minimum
peptide length of 8 residues. These 64,485 invariant
peptides of CoPSPATH database are taken as initial data to validate them as in silico drug target.
6. Evaluation of Parallel PLHoST.
Project Description: PLHoST is a proteomics tool developed in IGIB. Jalaja technology, Banglore is developing its parallel version.
7. Metagenomic Analysis of the Human Distal Gut Micro biome.
Project Description: Sequence assembly using different assembly softwares like, AMOS, Celera Assembler and Phrap. Identification of putative ORFs within the assembled contigs using BLASTX and identification of Gut Flora.