Scientist Solutions: Life Science Discussions

Thanks to our sponsors who make this site possible
rlanzara' Bench [how it works]
Space
My Bench Space is your space on Scientist Solutions, with both a private area where you can keep track of your account settings and favorite postings, and a public area where you can upload your picture, customize your profile, or start a blog

My Summary
Keeps a log of the topics you've started, the replies you've made, protocols or events you've posted, etc. Your summary will show up in your public profile.

My Blogs
You can create as many blogs as you like. They'll be viewable by anyone who looks at your profile, and they will also be indexed and listed in The Forums section of Scientist Solutions

My Lab Drawer (private)
As you browse through Scientist Solutions, you may see a topic, event, job or protocol that you'd like to store so that you can find it again easily. By clicking the "Save to My Bench Space" button next to any item on our site, you will put that item in your lab drawer for future reference.
You can also add fellow scientists to your lab drawer by clicking the "Save this scientist to My Bench Space" link next to that member's name in their posts or Bench Space profiles.

My PubMed Alerts (private)
This really cool tool allows you to set up email notifications whenever and article in your area of interest (specified by keyword is published in PubMed

My Account
Edit your contact information and control your email preferences and privacy settings

Close Window   




rlanzara
Member since: Jul 13, 2008
From: New York, United States
Status: Frog Egg
My points: 26    what's this
Name: [Privacy]
 


Change Picture

About My Research

I'm particularly interested in how our receptors function. This interest ranges from drug-receptor desensitization, down-regulation, tolerance, fade or tachyphylaxis to the molecular and biophysical description of G protein-coupled receptors (GPCRs) and their thiol, sulfhydryl or cysteine sensitivities to redox modulation. For those who may wish to understand my and my collaborator's work on the structure and function of G protein-coupled receptors, I’ve provided the following links to the papers that are most important for understanding this work. I like to bunch them into groups of three. First are:

Weber's Law Modeled by the Mathematical Description of a Beam Balance, Mathematical Biosciences 122: 89-94 (1994)

Method for determining drug compositions to prevent desensitization of cellular receptors, US Patent # 5,597,699 (1997)

Activation of G Protein-Coupled Receptors Entails Cysteine Modulation of Agonist Binding, J. Molecular Structure (Theochem), 430/1-3: 57-71 (1998)

The next three papers are:

Compositions to enhance the safety and efficacy of bio-pharmaceutical drugs. US Patent# 6,593,094 (2003)

Optimal Agonist/Antagonist Combinations Maintain Receptor Response by Preventing Rapid Beta-1 adrenergic Receptor Desensitization Intl. J. Pharmacol., 1(2): 122-131, (2005)

Molecular dynamics of a biophysical model for beta-2-adrenergic and G protein-coupled receptor activation Journal of Molecular Graphics and Modelling 25: 396-409 (2006)

Key words: Pharmacology, theory, signal transduction, molecular modeling, biophysics, mathematical modeling

My Affiliations:

Bio Balance, Inc.

Off the bench I enjoy:

not given