I'm particularly interested in how our receptors function. This interest ranges from drug-receptor desensitization, down-regulation, tolerance, fade or tachyphylaxis to the molecular and biophysical description of G protein-coupled receptors (GPCRs) and their thiol, sulfhydryl or cysteine sensitivities to redox modulation. For those who may wish to understand my and my collaborator's work on the structure and function of G protein-coupled receptors, I’ve provided the following links to the papers that are most important for understanding this work. I like to bunch them into groups of three. First are:

Weber's Law Modeled by the Mathematical Description of a Beam Balance, Mathematical Biosciences 122: 89-94 (1994)

Method for determining drug compositions to prevent desensitization of cellular receptors, US Patent # 5,597,699 (1997)

Activation of G Protein-Coupled Receptors Entails Cysteine Modulation of Agonist Binding, J. Molecular Structure (Theochem), 430/1-3: 57-71 (1998)

The next three papers are:

Compositions to enhance the safety and efficacy of bio-pharmaceutical drugs. US Patent# 6,593,094 (2003)

Optimal Agonist/Antagonist Combinations Maintain Receptor Response by Preventing Rapid Beta-1 adrenergic Receptor Desensitization Intl. J. Pharmacol., 1(2): 122-131, (2005)

Molecular dynamics of a biophysical model for beta-2-adrenergic and G protein-coupled receptor activation Journal of Molecular Graphics and Modelling 25: 396-409 (2006)

Key words: Pharmacology, theory, signal transduction, molecular modeling, biophysics, mathematical modeling

Biochemistry, Bioinformatics, Biophysics, Cell Biology, Computational Biology, Drug Discovery, Medicine, Neuroscience, Pharmacology