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parvoman
Member since: Jul 28, 2005
From: UK, Scotland
Status: Virology Moderator
My points: 963    what's this
Name: Jason King
 


Change Picture

About My Research

Using recombinant viruses as tools to transduce primary macrophages and other cells involved in inflammation reactions. Either over-expressing of knocking down a gene's expression. Virus of the moment: Lentivirus (VSV-G pseudotyped HIV vectors). Work being carried out within the MRC Centre for Inflammation Research, Edinburgh.

 

I have an interest in the hERG (human Ether-a-go-go Related Gene) in relation to its expression in many cancers (it is not expressed in the non-transformed cell counterparts). ERG is a multi-transmembrane domain, pore-forming potassium channel and almost all research into ERG is focussed on its activity in excitable cells - neurons and cardiomyocytes, where it is responsible for regulating the action potential (heart beat). ERG plays a part in regulating a cell's membrane potential and could therefore influence the type of cell-cell interactions that can occur. This could be important in relation to a tumour cell's ability to migrate away from the primary tumour or avoid being neutralized by cells of the immune system.

 

My Affiliations:

not given

My Publications:

No Publications found

Off the bench I enjoy:

Business Development / Entrepreneurship

Investments in Eastern Europe

Photography

Classic cars (late 50's - early 70's)